Expression of activator of CREM in the testis (ACT) during normal and impaired spermatogenesis: correlation with CREM expression
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منابع مشابه
Expression of activator of CREM in the testis (ACT) during normal and impaired spermatogenesis: correlation with CREM expression.
The cAMP-responsive element modulator (CREM) is involved in regulating gene expression in haploid spermatids. Transcriptional activity of the CREM protein is thought to be regulated by activator of CREM in the testis (ACT). Applying RT-PCR and in situ hybridization, cell-specific gene expression of ACT was demonstrated in man, cynomolgus monkey and mouse. During normal spermatogenesis, RT-PCR r...
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cAMP responsive element modulator (CREM) activators are specifically expressed in haploid germ cells prior to cell elongation and are essential for spermatid development in mice. Recent studies indicate that CREM activators are also involved in the process of spermatid maturation in men. Unlike the activators, CREM repressors were suggested to be absent from adult mouse and dog testes. The pres...
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Spermatogenesis is a complex differentiation process under the hormonal control of the hypothalamic-pituitary axis. The CREM gene encodes activators and repressors of cAMP-mediated gene transcription. The transcript corresponding to the activator isoform CREMtau is found at high levels in pachytene spermatocytes onwards. The CREMtau protein, however, is present only in post-meiotic spermatids w...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2004
ISSN: 1460-2407
DOI: 10.1093/molehr/gah012